Continuous crystallisation PAT: measurement choices and endpoint definitions
What to measure inline when crystallisation runs continuously, which PAT tools fit which regime, and how endpoint stops being a moment and becomes a window.
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14 articles tagged raman.
Transfer learning for spectroscopic classifiers: what the 2025-2026 papers say
Recent peer-reviewed work on transfer learning in Raman and NIR classifier training reports real gains on small labelled sets, but the cross-instrument and cross-matrix picture is still uneven.
Total nitrogen in fertiliser granules: measurement approaches for continuous production
Kjeldahl and Dumas remain the reference methods behind the total-N figure printed on every bag, but the plant floor wants a faster loop. What NIR, Raman, and LIBS can and cannot deliver on coated granules.
SERS substrates for industrial use: what changed in 2025 and 2026
Recent literature on SERS substrates points at flexible cellulose, 3D-printed metals, and uniformity-engineered nanostructures. We review what is useful for industrial work and what stays in the lab.
Bioprocess Raman analyzers: a focused 2026 review
Six vendors that matter for bioreactor monitoring - what each one is good at, what they are not, and the methodology we used to scope the field down from the full process Raman market.
Top 10 inline process Raman analyzers in 2026 - a ranked procurement edition
A companion to the non-ranked Spectrane process Raman buyer's guide. Ten vendors ordered on process-readiness, total cost of ownership, integration depth, chemometric maturity, and application coverage.
Peer-reviewed PAT validation work, late 2025 to spring 2026
Six recent peer-reviewed PAT papers worth a read: lean chemometrics for spectroscopic models, simpler bioprocess Raman regressions, at-line terahertz for crystallinity, and PAT-with-machine-learning past the bioreactor.
Calibration transfer between spectrometers: what the 2025-2026 papers changed
Three recent papers shift the calibration-transfer conversation: a low-rank fine-tuning method for deep Raman models, a vendor-to-vendor PDS/SST study, and single-compound shortcuts that sidestep paired transfer sets.
EMA Q&A on 3D-printed oral doses endorses inline NIR and Raman
EMA's March 2026 Q&A on 3D-printed solid oral doses accepts inline NIR and Raman spectroscopy for unit-level rejection, anchoring personalised micro-batches in the QbD and RTRT framework.
ACS Analytical Chemistry: three 2026 papers that matter for process analytics
March-May 2026 in ACS Analytical Chemistry: three threads for process analytics - close-focus Raman probes for turbid streams, deep-learning chemometrics, and open-source spectroscopy tooling.
USP chapters 858 and 1858 at five years - where pharmaceutical Raman stands
USP chapters 858 (Raman Spectroscopy) and informational 1858 replaced chapter 1120 on 1 August 2020. Almost six years on, handheld identity testing is the workhorse application; compendial method adoption is uneven.
Deep-learning chemometrics for process Raman: where the 2026 literature has landed
Five recent papers sketch where deep-learning chemometrics sits versus PLS for process Raman: a public bioprocess benchmark, two classifier benchmarks, self-supervised pre-training, and an explainability tool for GMP.
Time-gated Raman in 2025-2026: recent papers on fluorescent matrices
Recent peer-reviewed work on time-gated Raman - 512-pixel SPAD line arrays, Fourier-transform variants, and time-resolved use beyond fluorescence rejection - and what process-analytics teams can take from it.
Process Raman launches stayed quiet through spring 2026; portfolio moves dominated
A scan of vendor press rooms over the March-May 2026 window turns up no new process Raman analyzers from the major suppliers. The visible motion was in adjacent inline analytics and lab-grade Raman.