Bayesian chemometrics for process monitoring: what the 2025-2026 papers say
Recent papers push Bayesian uncertainty into the same workflows that PLS has owned for two decades. Where the ideas stick, and where they still stumble in production.
Air Liquide reported Q1 2026 sales of EUR 7,028 million on April 28, up 3.4 percent excluding currency and energy, with a record EUR 5.5 billion investment backlog and DIG Airgas closed in January.
Linde reported first-quarter 2026 sales of $8,781 million on May 1, with adjusted operating margin at 30.0% and a $7.1 billion contractual sale-of-gas project backlog.
BASF held sales close to flat, Dow swung to a GAAP Q1 loss on heavier costs, and DuPont raised full-year guidance after a 4 percent sales lift - three Q1 2026 prints that diverge sharply on margin trajectory.
EMA's Q&A on nitrosamines now runs across a main document and three appendices, with Appendix 1 refreshed on 24 June 2026. The methodology stack pushes analytical work firmly into LC-MS/MS at sub-ppb sensitivity.
MUR 22 was signed in December 2024 and public comments closed in March 2025. Sixteen months on, EPA has not finalized it. Labs face draft PFAS and PCB methods not yet required for NPDES monitoring.
Inline sensors keep SCR systems fed and flag misfilling, but the ppm-level contamination limits that ISO 22241 actually specifies still land in a laboratory. Here is where the two meet, and where they do not.
Recent papers push Bayesian uncertainty into the same workflows that PLS has owned for two decades. Where the ideas stick, and where they still stumble in production.
Recent literature on SERS substrates points at flexible cellulose, 3D-printed metals, and uniformity-engineered nanostructures. We review what is useful for industrial work and what stays in the lab.
The open-source stack that academic spectroscopy groups now teach with - mdatools, Quasar, pyMCR, rampy, pybaselines - has matured into something an industry hire arrives knowing. A field snapshot.
Metrohm opened a Houston application facility and helped shape ISO 18127 for combustion ion chromatography; here is what changed in its process analytics portfolio through mid-2026 and what did not.
Across BASF, Lanxess, Solvay, Syensqo, and Wacker, only Solvay and Syensqo published 2025 plant counts and outcomes against named digital platforms. The others restructured, paused, or went quiet.
Lonza's May 8 Q1 2026 trading update reaffirmed 11-12% CER sales growth guidance and a CORE EBITDA margin above 32%, with the Vacaville site fully integrated and the Visp and Portsmouth build-outs still on the books.
Acid number is the operator's read on alkyd esterification progress. This piece sets ISO 2114 potentiometric titration against inline NIR and Raman for continuous endpoint control.
Kjeldahl and Dumas remain the reference methods behind the total-N figure printed on every bag, but the plant floor wants a faster loop. What NIR, Raman, and LIBS can and cannot deliver on coated granules.
Urea- and melamine-formaldehyde resin producers judge polycondensation endpoint by offline viscosity. Inline Raman moves the call to the reactor, and the chemistry beats a single number.
Reactor deposits on the optical window are the main cause of process Raman drift. Comparing probe geometries, window materials, retraction schemes, and cleaning cycles across the leading vendors.
A side-by-side ranking of the open-source software stack practitioners actually use for Raman, IR, and NIR processing in 2026 - what each does best, where it stops short, and which combinations work in production.
A composite of practitioner conversations on FDA and EU inspections that put process analytical technology and chemometric models in scope. Inspectors read the lifecycle records, not the qualification protocols.
Synthesised observations from PAT-adjacent engagements where data scientists from web-product backgrounds collide with chemometricians steeped in PLS, ASTM E1655, and calibration transfer.
Techniques for online hydrocarbon monitoring in industrial effluent, what each of them actually measures, and how revised EU rules and existing US methods frame the discharge limits.
A multi-site rollout is not one deployment repeated N times. Five upstream decisions - governance, transfer, validation, change control, data flow - determine whether site N behaves like site one.